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• Scientific Track Record
• Team
  • Dr. Thomas Henkel
  • Bernard Becker
  • Dr. Matthias Gehling
  • Privat-Dozent Dr. Marc Stadler
  • Dr. Torsten Grothe
  • Dr. Bärbel Köpcke
  • Dr. Jens Bitzer
  • Dr. Philipp Wabnitz
  • Dr. Ernst Roemer
  • Erik Metz
  • Dr. Joachim Hans
  • Dr. Peter Reinemer
• Advisory Board

Director, Strategic Development ASEAN

Dr. Reinemer acquired 15 years experience in pharmaceutical R&D and research service business at different managerial positions. He joined InterMed Discovery following 10 years of Pharma R&D experience with Bayer HealthCare in Germany and Japan and 4 years of Pharma research service business experience with Proteros.

At Bayer, he most recently served as Director, Enabling Technologies, heading the protein biochemistry section comprising 25 FTE with responsibility for the establishment and operation of Bayer´s X-ray crystallography platform, assay development and protein supply. Subsequently, he joined Proteros Biostructures as Chief Scientific Officer with responsbility for all operations, the entire service project portfolio, and own research projects.  Most recently, he held the position of Head of Global Business Development for all Proteros service businesses, including the lead discovery services delivered by Proteros Fragments.

Through his functions, Dr. Reinemer has gained substantial experience in multiple indication areas,  technologies, planning and execution of drug discovery programs and mangement of strategic alliances embedded in global co-operations.

Dr. Reinemer was originally trained in Chemistry and obtained his Ph.D. with Nobel laureate Prof. Robert Huber at the Max-Planck-Institute for Biochemistry, Martinsried, Germany. He is author/co-author of about 50 peer-reviewed publications and reviews and serves as a referree for the Journal of Molecular Biology. 

Awards and Scholarships

Publications

Dirr HW, Mann K, Huber R, Ladenstein R, Reinemer P (1991). Class pi glutathione S-transferase from pig lung: purification, biochemical characterization, primary structure and crystallization. Eur. J. Biochem. 196, 693-698

Reinemer P, Dirr HW, Ladenstein R, Schäffer J, Gallay O, Huber R (1991). The three-dimensional structure of class pi glutathione S-transferase in complex with glutathione sulfonate at 2.3Å resolution. EMBO J. 10, 1997-2005

Dirr HW, Reinemer P (1991). Equilibrium unfolding of class pi glutathione S-transferase. Biochem. Biophys. Res. Commun. 180, 294-300

Hägele G, Reinemer P, Batz M, Mootz D (1992). Kristallstruktur und molekulare Dynamik eines Stereoisomeren von (P,P´,P´´,P´´´-Tetraphenyl)-1,1,2,2-ethantetrakisphosphinsäure-tetraisopropylester. Z. Naturforsch. 47B, 725-731

Reinemer P, Hägele G, Mootz D, Tyka R (1992). Crystal and molecular structure of 1-amino-benzylphosphonous acid monohydrate. Phosphorous Sulfur and Silicon 68, 53-58

Manoharan TH, Gulick AM, Reinemer P, Dirr HW, Huber R, Fahl WE (1992). Mutational substitution of residues implicated by crystal structure in binding the substrate glutathione to human glutathione S-transferase pi. J. Mol. Biol. 226, 319-322

Reinemer P, Dirr HW, Ladenstein R, Huber R, Lo Bello M, Federici G, Parker MW (1992). Three-dimensional structure of class pi glutathione S-transferase from human placenta in complex with S-hexylglutathione at 2.8Å resolution. J. Mol. Biol. 227, 214-226

Meyer DJ, Xia C, Coles B, Chen H, Reinemer P, Huber R, Ketterer B (1993). Unusual reactivity of Tyr-7 of GSH transferase P1-1. Biochem J. 293, 351-356

Xia C, Meyer DJ, Chen H, Reinemer P, Huber R, Ketterer B (1993). Chemical modification of GSH transferase P1-1 confirms the presence of Arg-13, Lys-44 and one carboxylate group in the GSH-binding domain of the active site. Biochem J. 293, 357-362

Sinning I, Kleywegt GJ, Cowan SW, Reinemer P, Dirr HW, Huber R, Gilliland GL, Armstrong RN, Ji X, Board PG, Olin B, Mannervik B, Jones TA (1993). Structure determination and refinement of human alpha class glutathione S-transferase A1-1, and a comparison with the mu and pi class enzymes. J. Mol. Biol. 232, 192-212

Karshikoff A, Reinemer P, Huber R, Ladenstein R (1993). Electrostatic evidence for the activation of the glutathione thiol by Tyr7 in pi-class glutathione transferases. Eur. J. Biochem. 215, 663-670

Reinemer P, Dirr HW, Huber R (1993). The three-dimensional structure of class pi glutathione S-transferase. In: Structure and function of glutathione transferases (Tew KD, Pickett CB, Mantle TJ, Mannervik B, Hayes JD, Ed.). CRC Press, Boca Raton, 65-74

Reinemer P, Grams F, Huber R, Kleine T, Schnierer S, Pieper M, Tschesche H, Bode W (1994). Structural implications for the role of the N-terminus in the „super-activation“ of collagenases - a crystallographic study. FEBS Lett. 338, 227-233

Bode W, Reinemer P, Huber R, Kleine T, Schnierer S, Tschesche H (1994). The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity. EMBO J. 13, 1263-1269

Steinbacher S, Seckler R, Miller S, Steipe B, Huber R, Reinemer P (1994). Crystal structure of P22 tailspike protein: interdigitated subunits in a thermostable trimer. Science 265, 383-386

Dirr HW, Reinemer P, Huber R (1994). Refined crystal structure of porcine class pi glutathione S-transferase (pGSTP1-1) at 2.1Å resolution. J. Mol. Biol. 243, 72-92

Dirr HW, Reinemer P, Huber R (1994). X-ray crystal structures of cytosolic glutathione S-transferases: implications for protein architecture, substrate recognition and catalytic function. Eur. J. Biochem. 220, 645-661

Tschesche H, Bläser J, Kleine T, Bode W, Reinemer P, Grams F, Schnierer S, Thomssen C, Schmitt M, Pache L, Jänicke F, Graeff H (1994). Structure and function of matrix metalloproteinases and their significance in breast cancer. In: Prospects in diagnosis and traetement of breast cancer. (Schmitt M, Graeff H, Kindermann G, Jänicke F, Genz T, Lampe B, Ed.). Elesevier, Amsterdam, 77-88

Tschesche H, Bläser J, Kleine T, Schnierer S, Reinemer P, Bode W, Maasjoshusmann U, Fricke C (1994). Inhibition of matrix metalloproteinases in rheumatoid arthritis and the crystallographic binding mode of a peptide inhibitor. Ann. N.Y. Acad. Sci. 732, 400-402

Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W (1995). X-ray structures of human neutrophil colagenase with peptide hydroxamate and peptide thiol inhibitors - implications for substrate binding and rational drug design. Eur. J. Biochem. 228, 830-841

Beißinger M, Lee SC, Steinbacher S, Reinemer P, Huber R, Yu M-H, Seckler R (1995). Mutations that stabilize folding intermediates of phage P22 tailspike protein: folding in vivo and in vitro, stability, and structural context. J. Mol. Biol. 249, 185-194

Egloff M-P, Cohen PTW, Reinemer P, Barford D (1995). Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate. J. Mol. Biol. 254, 942-959

Reinemer P, Dirr HW, Huber R (1995). X-ray structure methods for glutathione binding. In: Biothiols (Packer L, Ed.). Methods in Enzymology 251, 243-254

Reinemer P, Huber R (1995). Röntgenstrahlen in der Biochemie. In: Forschung mit Röntgenstrahlen - Bilanz eines Jahrhunderts 1895 - 1995. (Heuck FHW, Macherauch E, Ed.). Springer, Heidelberg, 402-426

Stöcker W, Grams F, Baumann U, Reinemer P, Gomis-Rüth F-X, McKay DB, Bode W (1995). The metzincins - topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases. Prot. Science 4, 823-840

Reinemer P, Prade L, Hof P, Neuefeind T, Huber R, Zettl R, Palme K, Schell J, Koelln I, Bartunik H-D, Bieseler B (1996). Three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana at 2.2Å resolution: structural characterization of herbicide conjugating plant glutathione S-transferases and a novel active site architecture. J. Mol. Biol. 255, 289-309

Reinemer P, Huber R (1996). Os Raios-X em Bioquímica. Química 61, 38-57

Bode W, Grams F, Reinemer P, Gomis-Rüth F-X, Baumann U, McKay DB, Stöcker W (1996). The metzincin-superfamily of zinc-peptidases. In: Intracellular protein catabolism. (Suzuki K, Bond J, Ed.). Adv. Exp. Med. Biol. 389, Plenum Press, New York, 1-11

Bode W, Grams F, Reinemer P, Gomis-Rüth F-X, Baumann U, McKay DB, Stöcker W (1996). The metzincins: a superfamily of structurally related metalloproteinases. Zoology 99, 237-246

Neuefeind T, Huber R, Reinemer P, Knäblein J, Prade L, Mann K, Bieseler B (1997). Cloning, sequencing, crystallization, and X-ray structure of glutathione S-transferase-III from Zea mais var. mutin: a leading enzyme in detoxification of maize herbicides. J. Mol. Biol. 274, 577-587

Neuefeind T, Reinemer P, Bieseler B (1997). Plant glutathione S-transferases and herbicide detoxification. Biol. Chem. 378, 199-205

Bieseler B, Fedtke C, Neuefeind T, Etzel W, Prade L, Reinemer P (1997). Maize selectivity of FOE 5043: degradation of active ingredient by glutathione S-transferases. Pflanzensch. Nachr. Bayer Engl. Ed. 50, 117-140

Bode W, Grams F, Reinemer P, Gomis-Rüth F-X, Baumann U, McKay DB, Stöcker W (1997). The metzincins: a new superfamily of zinc endopeptidases. In: The astacins. Structure and function of a new protein family. (Zwilling R, Stöcker W, Ed.). Verlag Dr. Kovac, Hamburg

Hage T, Reinemer P, Sebald W (1998). Crystals of a 1:1 complex between human interleukin-4 and the extracellular domain of its receptor alpha chain. Eur. J. Biochem., 258, 831-836

Hage T, Sebald W, Reinemer P (1999). Crystal structure of the interleukin-4 / receptor alpha chain complex reveals a mosaic binding interface. Cell, 97, 271-281

Zajc A, Neuefeind T, Prade L, Reinemer P, Huber R, Biesler B (1999). Herbicide detoxification by glutathione S-transferases as implicated form X-ray structures. Pestic. Sci., 55, 248-252
Reinemer P, Sebald W, Duschl A (2000). Der Interleukin-4 Rezeptor: vom Erkennungsmechanismus zur pharmakologischen Zielstruktur. Angewandte Chemie, 112, 2954-2966

Reinemer P, Sebald W, Duschl A (2000). The interleukin-4 receptor: from recognition mechanism to pharmacological target structure. Angewandte Chemie Int. Ed. 39, 2834-2846

Fuchikami K, Togame H, Sagara A, Satoh T, Gantner F, Bacon KB, Reinemer P (2002). A versatile high throughput screen for inhibitors of lipid kinase activity: development of an immobilized phospholipid plate assay for phosphoinositide 3-kinase gamma. J. Biomolec. Screen. 7, 441-450

Togame H, Shimazaki M, Yamato A, Watanabe S-I, Saito K, Reinemer P (2003). Development of a simple homogenous assay to screen for inhibitors of GlcNAc-6-sulfotransferases. Anal. Biochem., 315, 67-76

Roehrig S, Straub A, Pohlmann J, Lampe T, Pernerstorfer J, Schlemmer K-H, Reinemer P, Perzborn E (2005). Discovery of the novel antithrombotic agent BAY 59-7939 – an orally active, direct factor Xa inhibitor. J. Med. Chem., 48, 5900-5908

Hansen G, Harrenga A, Wieland B, Schomburg D, Reinemer P (2006). Crystal structure of full length topoisomerase I from Thermotoga maritima. J. Mol. Biol., 358, 1328-1340

Immler D, Greven S, Reinemer P (2006). Targeted proteomics in biomarker validation: detection and quantification of proteins using a multi-dimensional peptide separation strategy. Proteomics, 6, 2947-2958

Stadler M, Bitzer J, Mayer-Bartschmid A, Müller H, Benet-Buchholz J, Gantner F, Tichy H-V, Reinemer P, Bacon KB (2007). Lactacystin and salinosporamide analogues from a terrestrial streptomyces species. J. Nat. Prod., 70, 246-252

Togame H, Dodo R, Inaoka T, Reinemer P (2007). Development of a simple and robust assay to screen for inhibitors of sphingosine kinases. Assay Drug Dev. Technol., 5, 215-224

Barazza A, Götz M, Cadamuro SA, Goettig P, Willem M, Steuber H, Kohler T, Jestel A, Reinemer P, Renner C, Bode W, Moroder L (2007). Macrocyclic statine-based inhibitors of BACE-1. ChemBioChem., 8, 2078-2091

Patents

Bieseler B, Reinemer P, Hain R, Mann K, Reif, H-J, Thomzik JE. Desoxyribonucleic Acid coding for glutathione S-transferase and its use. WO 1996/23072, 23.01.1995 DE

Haning H, Schmidt G, Pernerstorfer J, Schmeck C, Müller U, Bischoff H, Vöhringer V, Reinemer P, Apeler H, Schmidt D, Jonghaus W, Faeste C, Zoche M, Hauswald M, Woltering M, Kretschmer A. Indoles for treating diseases that can be treated using thyroid hormones. WO 2001/70687, 23.03.2000 DE

Schmeck C, Müller U, Schmidt G, Pernerstorfer J, Bischoff H, Kretschmer A, Vöhringer V, Faeste C, Haning H, Hauswald M, Schmidt D, Zoche M, Apeler H, Jonghaus W, Reinemer P. Benzofuran derivatives. WO 2002/079181, 29.03.2001 DE

Shiroo M, Yamamoto N, Hayashi F, Floeckner J, Reinemer P, Encinas J, Watanabe S, Tajimi M, Kokubo T. Regulation of human transient receptor potential channel. WO 2003/087158, 16.04.2002 US

Bacon KB, Liu N, Reinemer P, Rohlff, C. Use of SHP-1 for the therapy of Asthma. WO 2003/105884, 18.06.2002 GB

Bacon KB, Herath HMAC, Liu N, Reinemer P, Rohlff C. Regulation of CAP-1. WO 2004/034062, 08.10.2002 GB

Stadler M, Seip S, Müller H, Mayer-Bartschmid A, Brüning M-A, Benet-Buchholz, J, Togame H, Dodo R, Reinemer P, Bacon KB, Fuchikami K, Matsukawa S, Urbahns K. Substituted Heterocycles. WO 2004/071382, 14.02.2003 EP

Hillebrand S, Oliver G, Wiese W-B, Kunz K, Ullmann A, Mattes A, Schreier P, Wachendorff-Neumann U, Kuck K-H, Loesel P, Malsam O, Reinemer P, Stadler M, Seip S, Mayer-Bartschmid A, Mueller H, Bacon K. Substituted 2-Pyrrolidone derivatives as fungicides and insecticides. WO 2006/005551, 12.07.2004 EP

Reinemer P, Gielen-Haertwig H, Rosentreter U, Li V, Harrenga A, Schomburg D, Niefind K, Hansen G. Crystal structure of enzyme and uses thereof. WO 2006/063792, 16.12.2004 EP