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Processes
As partners in business, our processes enable us to identify, to develop, and to perfect NP product solutions for clients and strategic partners.
Our custom IMD Bioprofiling can notably increase the probability of discovering LEAD structures and innovative projects and products with our comprehensive system of biological data. Designed from a wide selection of smartly chosen, pharmacologically relevant target assays, IMD can employ over 10,000,000 bioactivity data points on NP chemical matter. This is a proprietary data system that covers most pathomechanisms, target families, and roughly 50% of molecular principles of current medicines in the clinic. IMD Bioprofiling for individual NP compounds help predict the biological properties of NP structures. We can thereby generate targeted compound libraries, assess the potential value of primary hit findings and create new projects with significantly higher success rates.
With our NPInformatics data system, we have an unparalleled collection of proprietary data on taxonomy, origin, and access as well as public data collected over two decades. This accumulated knowledge, systematically acquired over the years as a part of the Bayer AG — and continually by IMD today — helps us generate innovative pipeline projects from scratch. By starting out with a stronger foundation, we "shorten" as well as "steepen" the learning curve for discovery, making our approach better than our competitors.
We identify promising LEAD candidates with the aid of a proprietary specialist system, NPsilico, that cross-references scientific literature as well as proprietary data on Natural Products. With this system, our researchers can locate new projects for pharmaceuticals according to specific indication groups and find relevant chemical structure clusters based on either a specific need or a desired effect.
IMD’s fractionation technology advances the processing of extracts by clipping unwanted components and improving sample quality and compatibility for biological testing. This technology has been developed and optimized in numerous HT screening campaigns and has proven to be superior. These Advanced Extracts can then be enriched and purified, leading to high-quality samples that are close to a pure Natural Product and are better than our competitors’.
A unique DEREPLICATION tool enables IMD to analyze sample mixtures as well as putative pure compounds more efficiently by eliminating known chemical structures and elucidating the unknown. We filter out what is already in use, allowing us to avoid redundancy and concentrate on novel chemical structures in NP compounds. This technology relies on tailored software and the uniqueness of our NP compound data. We can therefore provide a multiplicity of innovative LEAD candidates with relevant properties.
Our one of a kind approach enables us to do focused, holistic analyses of Natural Product sources that capitalize more fully on the chemical diversity of biological substances, thus enabling you to find better Natural Product leads more efficiently. We do not simply provide "more" NP LEAD candidates than any other but focus on quality and reliability as well.