Tuesday, September 07, 2010
Pharmaceutical Service
| Branch/Service | Pharma Service |
|---|
| Title: | Customized design and provision of reference libraries |
| Client description: | R&D based pharma company focussed on predefined targets or therapeutic areas |
| Client’s challenge: | - Lack of access to qualified chemical matter.
- Seeks one stop shop for procurement.
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| Client’s demand: | - Increase chemical diversity of own screening libraries to increase probability of success.
- Usage of Natural Products as benchmark to validate targets during assay development.
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| IMD’s strength: | - Available comprehensive NP libraries with world’s largest pure NP pool
- Corresponding proprietary biological data allows creation/tailoring of libraries to client’s needs.
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| IMD’s assignment: | - Customize screening pool in alignment with targeted indication or desired structural features
- Provision of a reference library for screening process
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| IMD’s approach: | - Database screening and identification of promising substance pools
- Compilation of a set or of libraries of compounds including full documentation.
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| Results: | - Increased probability of success (shown by higher hit rate).
- Check of client’s test systems (bioassay) allows final assessment of its validity.
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| Branch/Service | Pharma Service |
|---|
| Title: | Provision of high diversity premium NP libraries |
| Client description: | - R&D based pharmaceutical company seeking NP chemical diversity
- Or cooperation partner who seeks NP to complete his own range of services to third parties
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| Client’s challenge: | - Lack of own NP resources, know how, experience and without interest in setting up own NP research unit.
- Nevertheless needs to add new projects to pipeline.
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| Client’s demand: | - Access to biological sources,
- Access to technology platform in order to handle NP/transfer biological materials to screening samples.
- Sample quality compatible to his own processes and formats.
- Capability for HIT FOLLOW UP (Quality, reliability, efficiency, availability)
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| IMD’s strength: | - Suppliers network, biological source collection, sophisticated technology for high quality sample generation/preparation, meeting needs regarding formats and quantities,
- fully integrated technology platform comprising microbiology, fermentation, scale up facilities, top tier analytics (DEREPLICATION + STRUCTURE ELUCIDATION), isolation
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| IMD’s assignment: | - Provision of high diversity premium NP libraries
- guaranteed compatibility of samples,
- sustainable use and provision
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| IMD’s approach: | - Physical provision of screening samples in various qualities tailored to customer’s requirements,
- HIT FOLLOW UP in agreement/coordination with customer
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| Results: | - Validated, biologically active LEAD candidates with full STRUCTURE ELUCIDATION and preliminary/initial structure activity relation from derivatization projects.
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Pharmaceutical