Company Profile
Events
- Home>
- Company Profile>
- Team>
- Dr. Bärbel Köpcke
Dr. Bärbel Köpcke
Head Natural Product Dereplication
Dr. Bärbel Köpcke studied biology at the University of Kaiserslautern, Germany, where she obtained her PhD in the group of Prof. Dr. H. Anke in 1999. Prior to joining InterMed Discovery in February 2006 she was a post-doc at the Institute of Biotechnology and Drug Research in Kaiserslautern. There she gained experience in Natural Products research. Her main interests were the fermentation of microorganisms and the isolation of bioactive secondary metabolites including chemical analysis and assaying the metabolites in various biotests.
Current responsibilities
Dr. Bärbel Köpcke is responsible for the Natural Product dereplication platform at IMD. The dereplication is done with a state of the art LCMS-system including HR-MS and MSn and a proprietary database comprising IMD’s complete pure compound collection.
| Education and professional career | |
|---|---|
| since 02/2006 | InterMed Discovery GmbH |
| 2004-2005 | Biology and chemistry teacher |
| 2000-2004 | Postdoctoral research fellow at the Institute of Biotechnology and Drug Research in Kaiserslautern with Prof. Dr. H. Anke |
| 1996-1999 | PhD thesis at the University of Kaiserslautern (Biotechnology Department) and at the Institute of Biotechnology and Drug Research in Kaiserslautern with Prof. Dr. H. Anke |
| 1990-1996 | Biology studies at the University of Kaiserslautern |
Publications
Mayer, A., Köpcke, B., Anke, H. & Sterner, O. (1994): Dermatolactone, a cytotoxic fungal sesquiterpene with a novel skeleton. Phytochemistry 43, 375-376.
Köpcke, B., Mayer, A., Anke, H. & Sterner, O. (1999): Bioactive azo- and azoxyformamides from Lycoperdon pyriforme (Schaeff. ex Pers.). Natural Product Letters 13, 41-46.
Badi, M., Schuster, R.-P., Köpcke, B., Mayer, A., Sikora, R.A. & Anke, H. (2000): Screening of fungi for control activity towards root knot nematode Meloidogyne incognita and studies on the mode of action. Med. Fac. Landbouww. Univ. Gent 65/2b, 481-490.
Köpcke, B., Johansson, M., Sterner, O. & Anke, H. (2001): Biologically active secondary metabolites from the ascomycete A111-95 1. Production, isolation and biological activities. Journal of Antibiotics 55, 36-40.
Johansson, M., Köpcke, B., Anke, H. & Sterner, O. (2001): Biologically active secondary metabolites from the ascomycete A111-95 2. Structure elucidation. Journal of Antibiotics 55, 104-106.
Johansson, M., Köpcke, B., Anke, H. & Sterner, O. (2002): Cyclization of (-)-pregaliellalactone in the fungus Galiella rufa. Angewandte Chemie International Edition 41, 2158-2160.
Johansson, M., Köpcke, B., Anke, H. & Sterner, O. (2002): Synthesis of (-)-pregaliellalactone, conversion of (-)-pregaliellalactone to (-)-galiellalactone by mycelia of Galiella rufa. Tetrahedron 58, 2523-2528.
Köpcke, B., Weber, R.W.S. & Anke, H. (2002): Galiellalactone and its biogenetic precursors as chemotaxonomic markers of the Sarcosomataceae (Ascomycota). Phytochemistry 60, 709-714.
Schwarz, M., Köpcke, B., Weber, R.W.S., Sterner, O. & Anke, H. (2004): 3-Hydroxypropionic acid as a nematicidal principle in endophytic fungi. Phytochemistry 65, 2239-2245