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- Dr. Jens Bitzer
Dr. Jens Bitzer
Director Cosmetic Ingredients,
Head Structure Elucidation
Dr. Jens Bitzer studied chemistry at the Georg August University in Göttingen, where he obtained the degree of a ‘Dr. rer nat.’ under the supervision of Prof. Dr. A. Zeeck in 2005. In the research group for biomolecular chemistry he specialised in Natural Products chemistry. His main scientific interests include new secondary metabolites from natural sources and their applications in life sciences, crop protection and biochemical research. Dr. Jens Bitzer has extensive experience in structure elucidation of Natural Products, combined with substantial knowledge of biosynthetic pathways and chemical ecology. Coming from a postdoctoral research position at the university in Göttingen, he joined InterMed Discovery GmbH (IMD) in March 2006.
Current responsibilities
Dr. Jens Bitzer is responsible for Natural Products structure elucidation, based on 1D and 2D NMR spectrometry and advanced mass spectrometric methods. His expertise also includes fast dereplication of known metabolites using proprietary as well as public databases and software. The high accuracy of IMD's structure elucidation is assured by precise interpretation of analytical data and expert knowledge on taxonomy, biosynthetic pathways, scientific databases and literature.Additionally Dr. Bitzer is in charge of IMD's cosmetic projet pipeline and superviseschemical synthesis, derivatisation and lead optimisation studies within IMD's pharmacological projects.
| Education and professional career | |
|---|---|
| since 03/2006 | Director Cosmetic Ingredients and Head Structure Elucidation at InterMed Discovery |
| 2005-2006 | Postdoctoral research fellow at University of Göttingen, working on bioactive secondary metabolites from endophytic fungi |
| 2005 | Doctoral examination (Rigorosum) |
| 2001-2005 | Dissertation in the research group of Prof. Zeeck, Institute of Organic and Biomolecular Chemistry, University of Göttingen. |
| 1995-2001 | Chemistry studies. Diploma thesis in the field of Natural Products chemistry. |
Publications
J. Bitzer, M. Streibel, H.-J. Langer, S. Grond, First Y-type actiomycins from Streptomyces with divergent structure-activity relationships for antibacterial and cytotoxic properties, Org. Biomol. Chem. 2009, 7, 444-450
J. Bitzer, T. Laessoe, J. Fournier, V. Kummer, C. Decock, H.-V. Tichy, M. Piepenbring, D. Persoh, M. Stadler, Affinities of Phylacia and the daldinoid Xylariaceae, inferred from chemotypes of cultures and ribosomal DNA sequences, Mycol. Res. 2008, 112, 251-270.
J. Bitzer, B. Köpcke, M. Stadler, V. Hellwig, Y.-M. Ju, S. Seip, T. Henkel, Accelerated Dereplication of Natural Products, Supported by Reference Libraries, Chimia 2007, 61, 332-338.
M. Stadler, J. Bitzer, A. Mayer-Bartschmid, H. Müller, J. Benet-Buchholz, F. Gantner, H.V. Tichy, P. Reinemer, B.C. Bacon, Cinnabaramides A-G: Analogues of Lactacystin and Salinosporamide From a Terrestrial Streptomycete, J. Nat. Prod. 2007, 70, 246-252.
J. Bitzer, V. Gesheva, A. Zeeck: Actinomycins with Altered Threonine Residues in the beta-Peptidolactone, J. Nat. Prod. 2006, 69, 1153-1157.
J. Bitzer, A. Zeeck: 6-Deoxy-a-L-talopyranosides from Streptomyces sp., Eur. J. Org. Chem. 2006, 3661-3666.
L. Wang, T. Große, H. Stevens, T. Brinkhoff, M. Simon, L. Liang, J. Bitzer, G. Bach, A. Zeeck, H. Tokuda, S. Lang: Bioactive hydroxyphenyl-pyrrole-dicarboxylic acids from a new marine Halomonas sp.: production and structure elucidation, Appl. Microbiol. Biotechnol. 2006, 72, 816-822.
J. Bitzer, T. Große, L. Wang, S. Lang, W. Beil, A. Zeeck: New Aminophenoxazinones from a Marine Halomonas sp.: Fermentation, Structure Elucidation and Biological Activity, J. Antibiot. 2006, 59, 86-92.
J. Bitzer: Isolierung und Strukturaufklärung neuer Naturstoffe aus Bakterien und endophytischen Pilzen durch chemisches Screening, Dissertation, Universität Göttingen 2005. Published at Sierke Verlag, Göttingen 2005, ISBN 3-933893-31-3, and online at http://webdoc.sub.gwdg.de/diss/2005/bitzer/.
Edition of a variety of keywords for the encyclopedia ROEMPP online in the field of plant ingridients and plant physiology (Thieme Chemistry, Stuttgart, 2007 - 2009).