InterMed Discovery

Friday, September 10, 2010

Dr. Torsten Grothe

Director Functional Food Ingredients

Dr. Grothe holds a diploma degree and a PhD in Biochemistry. He has twelve years experience in all fields of Natural Products research, including biosynthesis & metabolic engineering. From 2002 to 2003 he was project leader for fungal Natural Products at ActinoDrug Pharmaceuticals. Dr. Grothe joined the Pharma Division of Bayer HealthCare in 2003. He led a research project for the discovery of crop protection agents from microbial and plant sources.
Dr. Grothe is currently Research Director for Functional Food Ingredients at IMD. 
 

Professional career
since 02/2006 Director Functional Food Ingredients
2003-01/2006 Project leader at Bayer HealthCare Natural Products Research
2002-2003 Project leader at ActinoDrug Pharmaceuticals

 

Education
1998-2002 Dissertation Martin-Luther-University Halle/Wittenberg;
Realisation of Dissertation at the Leibniz-Institute for Plant
Biochemistry, Halle
1995-1998 Biochemistry, Private University Witten/Herdecke
1993-1995 Food chemistry, University Wuppertal
1989-1992 Bio-technical Lab-Assistant, City of Cologne

 

Awards and scholarships
2005 PHOENIX Pharmazie-Wissenschaftspreis
2002 Luther-medal

 

Publications & Lectures

A. Regular publications in peer-reviewed journals

Stadler, M.; Baumgartner, M.; Grothe, T.; Mühlbauer, A.; Seip, S. & Wollweber, H. (2001). Concentricol, a taxonomically significant triterpenoid from Daldinia concentrica. Phytochemistry 56, 787 –793.

Grothe, T.; Lenz, R. & Kutchan, T.M (2001). Molecular Characterization of the Salutaridinol 7-O-Acetyltransferase Involved in Morphine Biosynthesis in Opium Poppy Papaver somniferum. J. Biol. Chem. 276, 30717-30723.

Hellwig, V.; Grothe T.; Mayer-Bartschmid, A.; Endermann, R.; Geschke, F.U.; Henkel, T. & Stadler, M. (2002). Altersetin, a New Antibiotic From Cultures of Endophytic Alternaria ssp. Taxonomy, Fermentation, Isolation, Structure Elucidation, and Biological Activities. J. Antibiotics 55, 881-892.

Kucht, S.; Groß, J.; Hussein, Y.H.A.; Grothe, T.; Steiner, U. & Leistner, E. (2004). Elimination of Ergoline Alkaloids from Ipomoea asarifolia (Convolvulaceae) by Fungicides. Planta 219, 619-625.

Grothe T. (2009) Using pharma technologies to generate fuctional food ingredients.  Innovations in Food Technology 44, 54-55

B. Plenary Lectures (national and international conferences) and seminars

Grothe, T. (2000). Molecular cloning and functional expression of acetyl coenzyme A:salutaridinol 7-O-acetyltransferase from Papaver somniferum. 3. Kurt-Mothes-Doktoranden-Workshop Sekundärstoffwechsel, Halle, Germany.

Grothe, T. (2003). Morphine Biosynthesis in Opium Poppy: Molecular cloning, functional Expression and Characterization of the Salutaridinol 7-O-acetyltransferase (SalAT) and purification of Thebaine synthase from the latex of the opium poppy Papaver somniferum. Institute for pharmaceutical Biology, University Tübingen, Germany

Grothe, T. (2006). Qualifizierte Naturstoffe als Basis zur Entwicklung neuer Produkte. 2. IIR-Jahrestagung Lebensmittel-Grenzprodukte, Hamburg, Germany.

Grothe, T. (2006). Aufmerksamkeit durch neue pflanzliche Extrakte. IIR-Forum pflanzliche Extrakte in Lebensmitteln und Nahrungsergänzungsmitteln, Nuremberg, Germany.

Grothe, T. (2007). Qualifizierte Naturstoffe als Basis zur Entwicklung innovativer Produkte - Von der Entdeckung bis zur klinischen Studie. 3. IIR-Jahrestagung Lebensmittel-Grenzprodukte, Cologne, Germany

C. Poster Presentations

Stadler, M.; Wollweber, H.; Henkel, T.; Mühlbauer, A.; Grothe, T.; Wetzstein, H.G. & Tichy, H.V. (1998). Secondary metabolism and genetic fingerprinting in Daldinia, Hypoxylon and other Xylariaceae. Sixth International Mycological Congress, Jerusalem, Israel.

Grothe, T.; Lenz, R. & Kutchan, T.M. (2000). Molecular cloning and functional expression of acetyl coenzyme A:salutaridinol 7-O-acetyltransferase from Papaver somniferum. Joint Meeting of the German Pharmaceutical Society, Society of Medicinal Plant Research and German Botanical Society: Biosynthesis and Accumulation of Secondary Products, Halle, Germany.

Hellwig, V.; Grothe, T.; Mayer-Bartschmid, A.; Henkel, T.; Endermann, R. & Stadler, M. (2001). Altersetin – A new antibacterial tetramic acid from endophytic Alternaria ssp. Gordon Research Conference Natural Products, Tilton, USA.

D. Patents

Grothe, T.; Zenk, M.H. & Kutchan, T.M. (2003): Salutaridinol 7-O-acetyltransferase and derivatives thereof. EP1270727; WO02101052.

Grothe, T. & Roemer, E. (2006): Plants extracts for use in brain modulation. EP06026244.