Company Profile

• Main
• Scientific Track Record
• Team
  • Dr. Thomas Henkel
  • Bernard Becker
  • Dr. Matthias Gehling
  • Privat-Dozent Dr. Marc Stadler
  • Dr. Torsten Grothe
  • Dr. Bärbel Köpcke
  • Dr. Jens Bitzer
  • Dr. Philipp Wabnitz
  • Dr. Ernst Roemer
  • Erik Metz
  • Dr. Joachim Hans
  • Dr. Peter Reinemer
• Advisory Board

Director Fermentation/Microbiology

Dr. Stadler has gained 20 years of experience in various all fields of Natural Products chemistry and basic and applied mycology and microbiology.

He received a grant by the “Studienstiftung des deutschen Volkes” and graduated with summa cum laude in 1993 in biology (Dept. Biotechnology, Kaiserslautern University, Germany, under supervision of Prof. H. Anke). His PhD thesis dealt with the discovery of bioactive compounds from invertebrate-associated fungi. A postdoctoral grant by the “Deutsche Forschungsgemeinschaft” later allowed him to research fungal chemical ecology at the Department of Natural Product Chemistry, Lund University, Sweden, (1994-1995) under supervision of Prof. O. Sterner. In 1995 he joined Bayer´s Natural Products research department, which he left in 2006 as Principal Research Scientist to take over his current position at IMD.

His current responsibilities still include IMD’s microbial culture collections, as well as fermentation, downstream processing, and isolation of Natural Products in gram scale. His expertise also includes e.g. microbial biotransformations, adaptation of screening technologies to Natural Products, and analytical chemistry. He co-authored more than 80 papers, patents, and book chapters and has acted as plenary speaker and symposium chair at various international conferences. As an internationally renowned expert on fungal taxonomy and chemotaxonomy, he maintains several scientific collaborations with leading mycologists and Natural Products chemists in Europe, America,. and Asia. Furthermore, he teaches mycology at Bayreuth University (Germany) and co-ordinates IMD's activities regarding various research grants that the company obtained from national und European funding institutions.

Selected Publications

2010

Castañeda Ruíz RF, Minter DW, Stadler M, Gené J, Guarro J, Cano J (2010) Two new anamorphic fungi from Cuba: Endophragmiella profusa sp. nov. and Repetoblastiella olivacea gen. & sp. nov. Submitted to Mycotaxon.

Fournier J, Köpcke B, Stadler M (2010) New species of Hypoxylon from Western Europe and Ethiopia. Accepted for publication by Mycotaxon.

Stadler M, Fournier J, Gardt S, Peršoh D (2010) The phylogenetic position of Rhopalostroma as inferred from a polythetic approach. Persoonia, in press.

Fournier J, Flessa F, Peršoh D, Stadler M (2010) Three new Xylaria species from Southwestern Europe. Mycol Progr., in press

Castañeda Ruíz RF, Heredia Abarca G, Arias Mota RM, Becerra Jernandez CI, Stadler M Saikawa M, Minter DW (2010) Anaselenosporella sylvatica gen. & sp. nov. and Pseudoacrodictys aquatica sp. nov., two new anamorphic fungi from Mexico. Mycotaxon 113: in press.

Castañeda Ruíz RF, Morillo O, Tovar B, Hernández Z, Iturriaga T, Minter DW Gené J, Guarro J, Stadler M (2010) Endogenospora, a new genus of anamorphic fungi from Venezuela. Mycotaxon 113: in press.

Læssøe T, Srikitikulchai P, Fournier J, Köpcke B, Stadler M (2010) Lepraric acid derivatives as chemotaxonomic markers in Hypoxylon aeruginosum, Chlorostroma subcubisporum and C. cyaninum, sp. nov. Fungal Biology, 114: 481-489.

Stadler M, Fournier J, Læssøe T, Decock C, Peršoh D, Rambold G (2010) Ruwenzoria, a new genus of the Xylariaceae from Central Africa. Mycol. Progr. 9:169–179.

Stadler M, Fournier J, Læssøe T, Chlebicki A, Lechat C, Flessa F, Rambold G, Peršoh D (2010) Chemotaxonomic and phylogenetic studies of Thamnomyces (Xylariaceae). Mycoscience 51: 189-207.

Castañeda Ruíz RF, Heredia Abarca G, Arias Mota RM, Becerra CI, Saikawa M, Minter DW, Stadler M (2010) Elotespora, an enigmatic anamorphic fungus from Tabasco, Mexico. Mycotaxon 111: 197-203.

Stadler M (2010) Book review of “Alternaria: an identification manual. By Emory G. Simmons”. Mycotaxon 110: 535-538.

Fournier J, Stadler M, Hyde KD, Duong LM (2010). The genus Rostrohypoxylon and two new Annulohypoxylon species from Northern Thailand. Fungal Diversity 40: 23–36

2009

Stadler M, Schulz B (2009) High energy biofuel from endophytic fungi? Trends in Plant Science 14: 353-355

Castañeda Ruíz RF, Pascholati Gusmão LF, Oliveira de Moraes Jr V, Heredia Abarca G, Saikawa M, Minter DW, Stadler M (2009) Two setose anamorphic fungi: Ampullicephala
gen. nov. and Venustosynnema grandiae sp. nov. Mycotaxon 109: 275–288.

Peršoh D, Melcher M, Graf K, Fournier J, Stadler M, Rambold G (2009) Molecular and morphological evidence for the delimitation of Xylaria hypoxylon. Mycologia 101: 256-268.

Castañeda Ruíz RF, Guerrero B, Adamo GM, Morillo O, Minter DW, Stadler M, Gené J, Guarro J (2009). A new species of Selenosporella and two microfungi recorded from cloud forest in Mérida, Venezuela. Mycotaxon 109: 63–74. 2009.

Castañeda Ruíz RF, Pascholati Gusmão LF, Rodrigues da Cruz AC, Heredia Abarca G, Iturriaga T, Guarro J, Saikawa M, Stadler M, Minter DW (2009) Phaeocandelabrum, a new genus of anamorphic fungi to accommodate Sopagraha elegans and two new species, Ph. callisporum and Ph. concinnum. Mycotaxon 109: 221–232.

Castañeda Ruíz RF, Iturriaga T, Heredia Abarca G, Minter DW, Gené J, Stadler M, Saikawa M, Silvera-Simón C (2009) Notes on Heteroconium and a new species from Venezuela. Mycotaxon 107: 225–237.

2008

Bitzer J, Læssøe T, Fournier J, Kummer V, Decock C, Tichy HV, Piepenbring M, Peršoh D, Stadler M (2008) Affinities of Phylacia and the daldinoid Xylariaceae, inferred from chemotypes of cultures and ribosomal DNA sequences. Mycol. Res. 112: 251-270.

Stadler M, Keller NP (2008) Paradigm shifts in fungal secondary metabolite research. Editorial to special issue. Mycol. Res.112: 251-270 (Special issue covered entire volume 112(2) of Mycol. Res.).

Stadler M, Fournier J, Læssøe T, Lechat C, Tichy HV, Piepenbring M (2008). Recognition of hypoxyloid and xylarioid Entonaema species from a comparison of holomorphic morphology, HPLC profiles, and ribosomal DNA sequences. Mycol. Progr. 7: 53-73.

Stadler M, Fournier J, Beltrán-Tejera E, Granmo A (2008) The “red Hypoxylons” of the Northern Hemisphere. In “A Festschrift in honor of Professor Jack D. Rogers (Glawe DA, Ammirati JF, eds.). North American Fungi 3: 73-125.

Vasilyeva L, Stadler M (2008) Pyrenomycetes of the Russian Far East 3. Three new Daldinia species (Xylariaceae). Mycotaxon 104: 284-296.

2007

Stadler M, Fournier J, Quang DN, Akulov AY (2007) Metabolomic studies on the chemical ecology of the Xylariaceae (Ascomycota). Nat. Prod. Comm. 2: 287-304.

Stadler M, Mayer-Bartschmid A, Seip S, Bitzer J, Müller H, Benet-Buchholz J, Gantner F, Tichy HV, Reinemer P, Bacon KB (2007) Cinnabaramides A-G, lactacystin and salinosporamide analogues from a terrestrial Streptomyces species. J. Nat. Prod. 70: 246-252.

Castañeda Ruiz RF, Heredia Abarca G, Arias RM, Saikawa M, Minter DW, Stadler M (2007) Anamorphic fungi from submerged plant material: Phaeomonilia pleiomorpha, P. corticola and Cacumisporium pleuroconidiophorum. Mycotaxon 100: 327-336.

Möhrle V, Stadler M, Eberz G (2007) Biosensor-guided screening for macrolides. Analyt. Bioanalyt. Chem. 388: 1117-1125.

Bitzer J, Köpcke B, Stadler M, Hellwig V,  Ju YM, Seip S, Henkel T (2007) Accelerated dereplication of natural products, supported by reference libraries. Chimia 51: 332-338.

Heredia Abarca G, Castañeda Ruiz RF, Arias RM, Saikawa M, Stadler M (2007) Anamorphic fungi from submerged plant material: Acumispora verruculosa, Pleurophragmium aquaticum, and P. miniumbonatum. Mycotaxon 101:89-97.

Castañeda Ruiz RF, Pascholati Gusmão LF, Guarro J, Stchigel AM, Stadler M, Saikawa M (2007). Two new anamorphic fungi from Brazil: Cacumisporium tropicale and Acrodictys irregularis. Mycotaxon 102: 91–99.

Castañeda Ruiz RF, Pascholati Gusmão LF, Guarro J, Stchigel AM, Stadler M, Saikawa M, Leão-Ferreira SM (2007). Two new anamorphic fungi from Brazil: Dictyochaetopsis polysetosa and Myrothecium compactum. Mycotaxon 103: 1–8.

2006

Quang DN, Stadler M, Fournier J, Tomita A, Hashimoto T (2006) Cohaerins C-F, four azaphilones from the xylariaceous fungus Annulohypoxylon cohaerens. Tetrahedron 62: 6349-6354.

Stadler M, Quang DN, Tomita A, Hashimoto T, Asakawa Y (2006) Production of bioactive metabolites during stromatal ontogeny of Hypoxylon fragiforme. Mycol. Res. 110: 811-820.

Castañeda Ruiz RF, Minter DW, Stadler M, Saikawa M, Camino-Vilaró M (2006) Anamorphic fungi from submerged leaves in Cuba: Brevicatenospora enteroproliferata gen. et sp. nov. and Beltraniopsis aquatica sp. nov. Mycotaxon 96: 151-158.

Quang DN, Stadler M, Fournier J, Asakawa Y (2006) Carneic acids A and B, two chemotaxonomically significant antimicrobial agents from the xylariaceous ascomycete, Hypoxylon carneum. J. Nat. Prod. 69: 1198-1202.

Stadler M, Fournier J (2006) Pigment chemistry, taxonomy and phylogeny of the Hypoxyloideae (Xylariaceae). Rev. Iberoam. Micol. 23: 160-170.

2005

Hellwig V, Ju YM, Rogers JD, Fournier J, Stadler M (2005) Hypomiltin, a novel azaphilone from Hypoxylon hypomiltum, and chemotypes in Hypoxylon sect. Hypoxylon as inferred from analytical HPLC profiling. Mycol. Progr. 4: 39 - 54.

Triebel D, Persoh D, Wollweber H, Stadler M (2005) Phylogenetic relationships among Daldinia, Entonaema and Hypoxylon as inferred from ITS nrDNA sequences. Nova Hedw. 80: 25-43.

Quang DN, Hashimoto T, Radulovic N, Fournier J, Stadler M, Asakawa Y (2005) Sassafrins A-D, new antimicrobial azaphilones from the fungus Creosphaeria sassafras. Tetrahedron 61: 1743-1748.

Quang DN, Hashimoto T, Nomura Y, Wollweber H, Hellwig V, Fournier J, Stadler M, Asakawa Y (2005) Cohaerins A and B, azaphilones from the fungus Hypoxylon cohaerens, and comparison of HPLC-based metabolite profiles in Hypoxylon sect. Annulata. Phytochemistry 65: 797-809.

Castañeda Ruiz RF, Heredia G, Arias RM, Stadler M, Minter DW (2005) Two Hyphomycetes from submerged plant material of México. Mycotaxon 91: 333-337.

Castañeda Ruiz RF, Stadler M, Saikawa M., Iturriaga T, Decock C, Heredia G (2005) Microfungi from submerged plant material: Zelotriadelphia amoena gen. et sp. nov. and Vanakripa fasciata sp. nov. Mycotaxon 91: 339-345.
Quang DN, Hashimoto T, Stadler M, Asakawa Y (2005) Dimeric azaphilones from the xylariaceous ascomycete Hypoxylon rutilum. Tetrahedron 61: 8451-8455.

Quang DN, Hashimoto T, Radulović N, Stadler M, Asakawa Y. (2005). Antimicrobial azaphilones from the xylariaceous inedible mushrooms. Int. J. Medicinal Mushrooms 7: 452-455.

Quang, DN, Hashimoto T, Stadler M, Radulovic N, Asakawa Y (2005) Antimicrobial azaphilones from the fungus Hypoxylon multiforme. Planta Med. 71: 1058-1072.

Stadler M., Hellwig V, Mayer-Bartschmid A, Denzer D, Wiese B, Burkhardt N (2005) Novel analgesic triglycerides from cultures of Agaricus macrosporus and other basidiomycetes as selective inhibitors of Neurolysin. J. Antibiot. 58: 775-786.

Stadler M, Læssøe T, Vasilyeva L (2005) The genus Pyrenomyxa and its affinities to other cleistocarpous Hypoxyloideae as inferred from morphological and chemical traits. Mycologia 97: 1129-1139.

Stadler M, Hellwig V (2005) Chemotaxonomy of the Xylariaceae and remarkable bioactive compounds from Xylariales and their associated asexual stages. Recent Res. Devel. Phytochem. 9: 41-93.

2004

Quang DN, Hashimoto T, Tanaka M, Stadler M, Asakawa Y (2004) Cyclic azaphilones daldinins E and F from the ascomycete fungus Hypoxylon fuscum (Xylariaceae). Phytochemistry 65: 469-473.

Stadler M, Ju YM, Rogers J.D. (2004) Chemotaxonomy of Entonaema, Rhopalostroma and other Xylariaceae. Mycol. Res. 108: 239-256.

Stadler M, Wollweber H, Jäger W, Briegert M, Venturella G, Castro JM, Tichy HV (2004) Cryptic species related to Daldinia concentrica and D. eschscholzii, with notes on D. bakeri. Mycol. Res. 108: 257-273.

Castañeda Ruiz RF, Heredia G, Arias RM, Saikawa M., Minter DW, Stadler M, Guarro J, Decock C (2004) Two new Hyphomycetes from rainforests of México, and Briansuttonia, a new genus to accommodate Corynespora alternarioides. Mycotaxon 89: 297-306.

Stadler M, Læssøe T, Simpson JA, Wollweber H (2004) A survey of Daldinia species with large ascospores. Mycol. Res. 108: 1025-1041.

Quang DN, Hashimoto T, Tanaka M, Stadler M, Asakawa Y (2004) Constituents of the inedible mushroom Hypoxylon rubiginosum. J. Nat. Prod. 67: 1152-1155.

Stadler M, Hellwig V (2004) PCR-based data and secondary metabolites as chemotaxonomic markers in HTS for bioactive compounds from fungi. In An, Z (ed.) Handbook of Industrial Mycology. Marcel Dekker, New York, pp. 269-307. 

Stadler M, Wollweber H, Fournier J (2004) A host-specific species of Hypoxylon from France, and notes on the chemotaxonomy of the "Hypoxylon rubiginosum complex”. Mycotaxon 90: 187-211.

2003

Hellwig V, Wittka R, Mauler F, Freitag J, Liu J, Ding ZH, Stadler M (2003) Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin. Arch. Pharm. Med. Chem. 336: 119-126.

Stadler M, Tichy HV, Katsiou E, Hellwig V (2003) Chemotaxonomy of Pochonia and other conidial fungi with Verticillium-like anamorphs. Mycol. Progr. 2: 95-122.

Hellwig V, Mayer-Bartschmid A, Greif G, Kleymann G, Zitzmann W, Tichy HV, Stadler M (2003) Pochonins A-F, Antiviral and antiparasitic resorcylic acid lactones from Pochonia chlamydosporia var. catenulata. J. Nat. Prod. 66: 829-837.

2002

Stadler M, Baumgartner M, Ide K, Popp A, Wollweber H (2002) Importance of ascospore ornamentation in the taxonomy of Daldinia. Mycol. Progr. 1: 31-42.

Hellwig V, Grothe T, Mayer-Bartschmid A, Endermann R, Geschke FU, Henkel T, Stadler M (2002)  Altersetin, a new antibiotic from cultures of endophytic Alternaria spp. Taxonomy, fermentation, isolation, structure elucidation, and biological activities. J. Antibiot. 55: 881-892.

Quang DN, Hashimoto T, Tanaka M, Baumgartner M, Stadler M, Asakawa Y (2002) Concentricols B, C and D, three novel squalene-type triterpenoids from the ascomycete Daldinia concentrica. Phytochemistry 61: 345-353.

Mühlbauer A, Triebel D, Persoh D, Wollweber H, Seip S, Stadler M (2002) Macrocarpones, novel metabolites from stromata of Hypoxylon macrocarpum and new evidence on the chemotaxonomy of Hypoxylon. Mycol. Progr. 1: 235-248.

Quang DN, Hashimoto T, Tanaka M, Baumgartner M, Stadler M, Asakawa Y (2002) Chemical constituents of the ascomycete Daldinia concentrica. J. Nat. Prod. 65: 1869-1874.

Quang DN, Hashimoto T, Baumgartner M, Stadler M, Tanaka M, Asakawa Y (2002) Squalane and lanostane triterpenoids from the Ascomycete fungus Daldinia concentrica. In Proceedings of the 46th Symposium on the Chemistry of Terpenes, Essential Oils, and Aromatics (TEAC) and International Symposium on Essential Oils (ISEO). Tokushima, Japan, pp. 347-349.

2001

Stadler M, Wollweber H, Mühlbauer A, Henkel T, Wollweber H, Asakawa Y, Hashimoto T, Rogers JD, Ju YM, Wetzstein HG, Tichy HV (2001) Secondary metabolite profiles, genetic fingerprints and taxonomy of Daldinia and allies. Mycotaxon 77: 379-429.

Stadler M, Baumgartner M, Grothe T, Mühlbauer A, Seip S, Wollweber H (2001) Concentricol, a taxonomically significant triterpenoid from Daldinia concentrica. Phytochemistry 56: 787-793.

Wollweber H, Stadler M (2001) Zur Kenntnis der Gattung Daldinia in Deutschland und Europa. Z. Mykol. 67: 3-53.

Stadler M, Baumgartner M, Wollweber H, Rogers JD, Ju YM (2001)  Daldinia decipiens sp. nov. and notes on some other European Daldinia spp. inhabiting Betulaceae. Mycotaxon 80: 167-177. 

Stadler M, Baumgartner M, Wollweber H (2001) Three new Daldinia species with yellow stromatal pigments. Mycotaxon 80: 179-196.

Stadler M, Bauch F, Henkel T, Mühlbauer A, Müller H, Spaltmann F, Weber K (2001) Antifungal actinomycete metabolites discovered in a differential cell-based screening using a recombinant TOPO1 deletion mutant strain. Arch. Pharm. Med. Chem. 334: 143-147.

Stadler M, Wollweber H, Mühlbauer A, Asakawa Y, Hashimoto T, Rogers JD, Ju YM, Wetzstein HG, Tichy HV (2001) Molecular chemotaxonomy of Daldinia and other Xylariaceae. Mycol. Res. 105: 1191-1205.