InterMed Discovery

Tuesday, September 07, 2010

Dr. Matthias Gehling

Director Operations

Dr. Matthias Gehling has over 16 years of experience in Natural Products research, including 12 years of industrial drug discovery with Bayer AG and Bayer HealthCare AG, Germany. He gained extensive experience in lead discovery for the Life Science areas Pharma, Animal Health and Crop Protection. Prior to joining InterMed discovery in 2006 he was Director – Enabling Technologies Natural Product Research at Bayer HealthCare. He headed an interdisciplinary team for Natural Products Chemistry, Analytics, Biology, Scale-up fermentation and downstream processing, covering all aspects of industrial Natural Product research.

Several cooperation projects with international partners have been initiated and monitored by him. He co-authored several patents and papers on biological active Natural Products and has been invited speaker to some international conferences.

Dr. Gehling received his Ph.D. in Chemistry in 1989 from the University of Münster, Germany with an emphasis on studies towards biosynthetic pathway analysis by advanced radio-labeled precursor feeding.

 

Professional career
since 02/2006 InterMed Discovery GmbH, Director Operations, Member of the Board of Directors
2003-2006 Director of Bayer HealthCare AG Pharma Natural Products Research
2001-2003 Director of Bayer AG Pharma Life Science Center Natural Products Chemistry
1998-2001 Lab-Head Bayer AG Pharma Life Science Center Natural Products Chemistry
1994-1998 Lab-Head Bayer AG Central Research Natural Products Research
1990-1994 Bayer AG Textile processing Chemistry Research and Development

 

Education
1989 PhD Studies in Chemistry, University of Münster

 

Publications

A. Regular publications in peer-reviewed journals

Velten R, Erdelen C, Gehling M, Göhrt A, Gondol D, Lenz J, Lockhoff O, Wachendorff U, Wendisch D (1997) Cripowellin A and B, a Novel Type of Amaryllidaceae Alkaloid from Crinum powellii. Tetrahedron Letters 39, 1737-1740.

Nugroho B-W, Edrada R-A, Wray V, Witte L, Bringmann G, Gehling M, Proksch P (1999) An insecticidal rocaglamide derivatives and related compounds from Aglaia odorata (Meliaceae). Phytochemistry 51, 367-376.

Eisenbarth S, Gehling M, Harder A, Steffan B (2002) Pentaproins A, B and C: disulfides from the marine bryozoan Pentapora fascialis. Tetrahedron 58, 8461-8464

B. Reviews, book chapters, and contributions published in conference proceedings

Velten R, Dyker H, Gehling M, Gutbrod O, Lieb F, Schoop A (1999) Natural products and their role in pesticide discovery. In Bioorganic Chemistry, Highlights and New Aspects, Ed. Diederichsen U, Lindhorst T-K, Westermann B, Wessjohann L-A, Wiley-VCH, p 18-27

C. Plenary Lectures (national and international conferences) and seminars

Gehling M (2003). Future potential of natural products as quality leads, attempts for a qualitative and quantitative assessment. — Plenary lecture. CHI coference "Diversity-Oriented Synthesis and Natural Product Chemistry", Boston, MA, USA, October 2003

Gehling M (2004). Future potential of natural products as quality leads, attempts for a qualitative and quantitative assessment. — Plenary lecture. ACS meeting, Woburn, MA, USA, May 2004

D. Poster Presentations and Short lectures

Gehling M, Lenz J, Lockhoff O, Velten R (1997) Neuartige, insektizid wirksame Alkaloide aus Crinum powellii - Cripowellin A und B. — Poster presentation/Short lecture. 9. Irseer Naturstofftage der DECHEMA. Irsee, Germany.

Wirth R, Gehling M, Huber R, Ruhland S, Steffan B, Schütt C, Wanner G (2001). Isolation of a spiral shaped bacterium from the marine octacoral Alcyonium digitatum. — Poster Presentation Annual meeting of Mycologists, Oldenburg, Germany.