Company Profile
Events
- Home>
- Company Profile>
- Team>
- Dr. Thomas Henkel
Dr. Thomas Henkel
Managing Director
Dr. Henkel acquired more than 15 years of experience in Pharma R&D at different managerial positions. Before he co-founded IMD, he served as vice president at Bayer HealthCare Pharma Research and Development Dr. Henkel headed the department of enabling technologies responsible for Target ID/validation, bioinformatics, protein biochemistry and Natural Product lead ID comprising 64FTEs. Since the year 2000 he served as a member of the European research committee as well as the international research committee bearing responsibility for portfolio management and strategic decision making of Bayer HealthCare Pharma research at the European site and globally, respectively.
Dr. Henkel is organic chemist by training and obtained his PhD with Prof. Zeeck at the University of Göttingen, Germany. Before he joined Bayer, he worked with Prof. Vederas in Canada in the area of biochemistry and NMR analytics. Within Bayer he started as medicinal chemist and received over time several responsibilities, e.g. extramural repository sample acquisition, operation of scientific co-operations with China; 1998 he became director of the Natural Product chemistry department. In 2000 he got promoted as the head of the Bayer life science centre and since end of 2002 he was leader of the department of enabling technologies.
With his functions, Dr. Henkel gained experiences in multiple indication areas, technologies, project management as well as processes regarding productive lead discovery, embedded in a global co-operation environment. He is author of more than 20 peer reviewed publications in the field of Natural Product and bio-chemistry.
| Professional career | |
|---|---|
| since 02/2006 | Co-founder and Managing Director of InterMed Discovery GmbH |
| 2004 | Vice-President of Bayer Healthcare Pharma Research and Development |
| 2003-2005 | Head of "Enabling Technologies" at Bayer Healthcare |
| 2001 | Procura (Bayer AG) |
| 2000-2005 | Member of the European research committee as well as the international research committee bearing responsibility for portfolio management and strategic decision making of Bayer HealthCare Pharma research at the European site and globally, respectively |
| 2002 | Head of the Bayer life science centre |
| 1998 | Director of the Natural Product chemistry department |
| 1990-1992 | Post-doc researcher postion with Prof. J.-C. Vederas, University of Alberta, Canada. Research in the field of peptide- and proteinbiochemics, biology and NMR-Analysis (3 publications) |
| Awards and scholarships | |
|---|---|
| 2008 |
Innovative Ideas on the slimming field Award 2008 |
| 1990 | Liebig scholarship (junior professor/ "Habilitanden Stipendium"; VCI) |
| 1988 | Doctoral scholarship of Verband der Chemischen Industrie (VCI) |
| 1987 | Gustav-Tammann Award for the best diploma of the year at Göttingen University |
Publications
Total Synthesis and Initial Structure-Activity Relationships of Longicatenamycin A, Franz von Nussbaum, Sonja Anlauf, Christoph Freiberg, Jordi Benet-Buchholz, Jens Schamberger, Thomas Henkel, Guido Schiffer and Dieter Häbich, ChemMedChem 2008, 3, 1-9
Accelerated Dereplication of Natural Products, Supported by Reference Libraries, Jens Bitzer, Bärbel Köpcke, Marc Stadler, Veronika Hellwig, Yu-Ming Ju, Stephan Seip and Thomas Henkel*, Chimia, 2007
Scouting nach neuen innovativen Wirkstoffen aus der Natur, Dr. Thomas Henkel, GIT Magazin, 10/2006
Fu Xiang, Tan NingHua, Jiang LiHua, Jia RuiRui, Ji ChangJiu, Lando, J., Fekete, A., Mueller, H., Henkel, T., Acta Botanica Yunnanica, 2003 (Vol. 25) (No. 6) 724-729
Huang Y., Mühlbauer A., Henkel T., Liu J.; Three Novel Taccalonolides from the Tropical Plant Tacca subflaellata Journal Natural Products 2002
Jiang L-H., Tan N.-H., Yang Y.-B., Wang J.-S., Fu X., Johannsen L, Müller H., Henkel T.; Search for antibacterial activity out of extracts and fractions from plant derived sources targeting enoylpyruvate transferase Acta Pharmacologica Sinica, 2002
Hellwig V., Grothe T., Mayer-Bartschmid A., Endermann R., Geschke F.-U., Henkel T., Stadler M.; Altersetin, a New Antibiotic from Cultures of Endophytic Alternaria spp. Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activities Journal of Antibiotics 2002, 55, 10: 881-892
Huang Y., Liu J., Mühlbauer A., Henkel T.; Three Novel Taccalonolides from the Tropical Plant Tacca subflaellata, Helvetica Chimia Acta 2002, 85, 2553-2558
Liu J., Henkel T.; Traditional Chinese Medicine (TCM): are polyphenols and saponins the key ingredients triggering biological activities? Current Medicinal Chemistry, 2002, 9, 1241-1253
Stadler Marc, Wollweber Hartmund, Mühlbauer Andrea, Henkel Thomas, Asakawa Yoshinori, Hashimoto Toshihiro, Ju Yu-Ming, Rogers Jack D., Wetzstein Heinz-Georg, Tichy Hans-Volker; Secondary Metabolite Profiles, Genetic Fingerprints and Taxonomy of Daldinia and Allies. Mycotaxon 2001, 77, 379-429
Stadler Marc, Bauch Frank, Henkel Thomas, Mühlbauer Andrea, Müller Hartwig, Spaltmann Frank, Weber Karlheinz; Antifungal Actinomycte Metabolites Discovered in a Differential Cell-Based Screening Using a Recombinant TOPO1 Deletion Mutant Strain, Arch. Pharm. Pharm. Med. Chem. 2001, 334, 143-147
Henkel Thomas, Brunne Roger M., Müller Hartwig, Reichel Felix; Statistical Investigation into the Structural Complementary of Natural Products and Synthetic Compounds, Angew. Chem. Int. Ed. 1999, 38, No. 5
Stadler Marc, Henkel Thomas, Müller Hartwig, Weber Karlheinz, Schlecker
Harald; Identification of alkaloids and polyketices in an Actinomycete by high-performance liquid chromatography with mass spectromectric and UV-visible detection, J. Chromatogr.A 1998, 818, 187-1985
Hartwig W., Henkel T.; Significance of natural products in modern pharma research, Part 2: Drugs for cancer therapy, lipid lowering and hepato protection BIOforum – GIT VERLAG; Darmstadt, 1994, 17, 170-172
Hartwig W., Henkel T.; Significance of natural products in modern pharma research, Part 1: Secondary metabolites as drugs as well as lead structures for their development BIOforum – GIT VERLAG; Darmstadt, 1994, 17, 114-116
Worobo Randy W., Henkel Thomas, Sailer Miloslav, Roy Kenneth L., Vederas John C., Stiles Michael E.; Characteristics and genetic determinant of a hydrophobic peptide bacteriocin, carnobacteriocin A, produced by Carnobacterium piscicola LV17A Microbiology 1994, 140, 517-526
Sailer Miloslav, Helms Gregory L., Henkel Thomas, Niemczura Walter P., Stiles Michael E., Vederas John C.; N-and C-Labeled Media from Anabaena sp. For Universal Isotopic Labeling of Bacteriocins: NMR Resonance Assignments of Leucocin A from Leuconostoc gelidum and Nisin A from Lactococcus lactis, ochemistry 1993, 32, 310-318
Udvarnoki Györgyi, Henkel Thomas, Machinek Reinhard, Rohr Jürgen; Biosynthetic Origin of the Oxygen Atoms of Aquayamycin: Aspects for the Biosynthesis of the Urdamycin Family and for Aquayamycin-Containing Angucycline Antibiotics in General, J. Org. Chem. 1992, 57, No. 4
Thomas Henkel, Miloslav Sailer, Gregory L. Helms, Michael E. Stiles & John C. Vederas: NMR Assignment of Leucocin A, a Bacteriocin from Leuconostoc gelidum, Supported by a Stable Isotope Labeling Technique for Peptides and Proteins. J. Am. Chem. Soc 1992, 114, 5, 1898-1900
K. U. Bindseil, T. Henkel, A. Zeeck, D. Bur, D. Niederer & U. Sequin: The absolute configuration of sphydrofuran, a widespread metabolite from streptomyces. Helv. Chim. Acta 1991, 74, 1281-1286
Thomas Henkel, Sabine Breiding-Mack, Axel Zeeck, Susanne Grabley, Peter E. Hammann, Klaus Hütter, Gudrun Till, Ralf Thiericke and Joachim Wink: Secondary metabolites by chemical screening, 18. Narbosines, new carbohydrate metabolites from streptomyces. Liebigs Ann. Chem. 1991, 575-580
Thomas Henkel & A. Zeeck: Sekundärstoffe aus dem chemischen Screening, 16. Inthomycine, neue Oxazol-triene aus Streptomyces sp. Liebigs Ann. Chem. 1991, 367-373
T. Henkel & A. Zeeck: Secondary metabolites by chemical screening, 15. Structure and absolute configuration of naphthomevalin, a new dihydro-naphthquinone antibiotic from Streptomyces sp. The Journal of Antibiotics 1991, 44, 665-669
T. Henkel & A. Zeeck: Derivatives of saquayamycin A and B. Regio- and diastereoselective addition of alcohol at the L-aculose moiety. "The Journal of Antibiotics" 1990, 43: 830-837
T. Henkel, J. Rohr, J.M. Beale & L. Schwenen: Landomycins, new angucycline antibiotics from "Streptomyces" sp. II. Structural studies on landomycin A-D. "The Journal of Antibiotics" 1990, 43, 492-503
T. Henkel: Neue Naturstoffe aus einem modifizierten chemischen Screening und Strukturaufklärung der cytostatisch wirksamen Landomycine. Dissertation, Göttingen 1990
T. Henkel, T. Ciesiolka, J. Rohr & A. Zeeck: Urdamycins, new angucycline antibiotics from "Streptomyces fradiae". V. Derivatives of urdamycin A. "The Journal of Antibiotics" 1989, 42, 299-311
T. Henkel: Derivate der Cytostatica Urdamycin A sowie der Saquayamycine A und B als Beitrag zur Struktur-Wirkungsbeziehung von Angucyclin-Antibiotica. Diplomarbeit, Göttingen 1987